Out of curiosity, what’s your general fitness and interest in activity?
Even though cycling things will most likely be faster than alternatives, you’ll be out in cold, wet, wind, and/or dark a lot of the time – you’re going to need to like your commute to actually stick with it.
Part of liking your commute is liking your bike. You’re going to spend a lot of time on that bike so there’s a strong argument to be made for putting your money where your time and passion are. So do this on a bike that really speaks to you.
The distance is very doable for a healthy middle aged person or younger person and can be invigorating rather than tiring. This might sound like a long commute if it’s new to you, but you’ll get used to it quickly (I’d guess 2 or 3 months) and it’s no big deal once you have.
For a distance like that, speed matters. Powering a heavy slow bike that far day after day, year after year will not be fun. So one of the decisions you need to make is whether you’ll get your speed from your legs and a faster bike or going the electric motor route.
If you go the former route, the fitness base you’d get from riding that can be life changing. Things that would have been outright inaccessible before become easy. Physical strength and stamina are very handy things to have in regular life, and the older you get, the bigger deal that is.
As a long time observer of other distance commuters, the people who seem to stick with it overwhelmingly have faster lighter bikes. Electric riders I see tend to stick with it only for a few months, the notable exception being cargo bikes and the lot that an especially dedicated person uses as a substitute for a car.
As much as I hate changing tires, I still think the PDX obsession with flats is misguided. Roads are good here. I get maybe one flat ever 1500 miles or so out here, and getting flat resistant tires only reduces, not eliminates them. If your route is particularly bad with specific hazards such as broken glass, metal wires, and the like, it could be worth choosing something more durable, but roads here are generally good and there’s always a place you can pull off and work if you have to.
My own experience is that riding heavy, slow, tires with a terrible ride isn’t fun. When I started, I got the most flat resistant I could. I’ve tried virtually all of them and spent years using them, but over time I decided the actual ride that you experience every time you go out was more important than a few more flats per year. A heavy tire is going to slow you WAY more down than a heavier frame. Having said all that, if you go the electric route, may as well get bombproof tires since your bike will already weigh a ton an the motor will be dealing with the extra work.